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KMID : 0369819920220030237
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Jorunal of Korean Pharmaceutical Sciences
1992 Volume.22 No. 3 p.237 ~ p.240
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Preparation and Characterization of Poly ( γ - benzyl L - glutamate ) / Poly ( ethylene oxid ) - Lactoselactone Block Copolymers and Their Microspheres
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김영훈/KIm YH
조종수/성용길/정병호/이강춘/Cho CS/Sung YK/Chung BH/Lee KC
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Abstract
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A series of biodegradable block copolymers consisting of poly(γ?benzylL?glutamate) (PBLG) and poly(ethylene oxide) (PEO)-lactoselactone were prepared by polymerization of PEO-lactoselactone and γ?benzyl L-glutamate-N-carboxyanhydride and characterized by IR and NMR. From circular dichroism measurements, it was found that the polymers exist in the α?helical conformation. Block copolymer microspheres were prepared by solvent-extraction-precipitation method for their primary evaluation for medical and biological applications.
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KEYWORD
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PBLG-PEO-lactoselactone, Microspheres, Polypeptide, Poly(ethylene oxide)
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